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| 1981 | Kyowa Medex Co.,Ltd. established as a solely owned subsidiary of Kyowa Hakko focusing on developing, manufacturing and marketing in vitro diagnostics. |
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| 1987 | “Determiner DUPAN-2" EIA-based tumor marker |
| 1990 | A new plant and research laboratories constructed in Shizuoka Prefecture. |
| 1994 | “Determiner HDL-C" for the direct measurement of HDL-Cholesterol |
| 1995 | “Determiner HbA1c" immuno particle assay-based diabetes test reagent. |
| 1996 | “Determiner L HDL-C", Commencement of export to worldwide after receipt of the world's first approval from CDC. |
| 1997 | “HM-JACK", the fully automatic Human hemoglobin analyzer for the fecal occult blood test The Fuji plant ISO9001certified. |
| 1998 | “Determiner L LDL-C", “DM-JACK" the automatic analyzer for diabetes tests. |
| 2001 | “AP-96", the fully automatic microplate EIA analyzer The Fuji plant ISO14001 certified. |
| 2002 | “Determiner BNP", the cardiac failure marker. |
| 2003 | ISO13485 certified. |
| 2006 | “Metabolead RemL-C" launched |
| 2008 | Kyowa Hakko Kirin Co., Ltd. established under capital and strategic alliance of Kyowa Hakko Kogyo and Kirin Pharma. “Metabolead HDL-C” launched |
| 2009 | CL-JACK launched (Domestic only) |
| 2010 | HM-JACKarc launched |